These hazards do not stand alone.
They can feed off one another and exacerbate effects on the human body, which are being studied using ground-based analogs, laboratories, and the International Space Station.
The resulting data, technology, and methods serve as a knowledge bank from which scientists can extrapolate to multi-year interplanetary missions.
Space Radiation is considered one of the most hazardous aspects of spaceflight.
Isolation and Confinement can cause behavioral responses among groups of people far from Earth who are isolated and confined in a small space over a long period of time.
Astronauts' entire bodies – muscles, bones, inner ear, and organs – must adjust to the new gravities encountered on the space station or their spacecraft, as well as on the Moon, Mars, and Earth once they return home.
Maintaining a safe ecosystem inside a spacecraft presents unique challenges, from ensuring optimal temperatures, pressures, and lighting, to reducing noise, monitoring microbial communities, and tracking immune responses.
Crews must be carefully chosen, trained, and supported to ensure they can work effectively as a team for months or years in space.
On Mars, astronauts would need to live and work in three-eighths of Earth’s gravitational pull for up to two years.
Throughout this time, their bodies – muscles, bones, inner ear, and organs – will be adjusting to new gravitational loads.